General Information

  • ID:  hor004903
  • Uniprot ID:  P42997
  • Protein name:  Phasvatocin
  • Gene name:  NA
  • Organism:  Scyliorhinus canicula (Small-spotted catshark) (Squalus canicula)
  • Family:  Vasopressin/oxytocin family
  • Source:  animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Scyliorhinus (genus), Scyliorhinidae (family), Carcharhiniformes (order), Galeoidea (superorder), Galeomorphii, Selachii (infraclass), Elasmobranchii (subclass), Chondrichthyes (class), Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005179 hormone activity; GO:0005185 neurohypophyseal hormone activity
  • GO BP:  GO:0007165 signal transduction
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  CYFNNCPVG
  • Length:  9
  • Propeptide:  CYFNNCPVG
  • Signal peptide:  NA
  • Modification:  T9 Glycine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Displays oxytocic activity on rat uterus.
  • Mechanism:  NA
  • Cross BBB:  NO
  • Target:  NA
  • Target Unid:  NA
  • IC50: antidiuretic activity 408 IU/mg ( PubMed ID: 17258819 )
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: 1.06±0.19 (fast phase) minutes; /63.6 seconds ( PubMed ID: 17258819 )

Structure

  • Disulfide bond:  1-6
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004903_AF2.pdbhor004903_ESM.pdb

Physical Information

Mass: 115903 Formula: C44H61N11O13S2
Absent amino acids: ADEHIKLMQRSTW Common amino acids: CN
pI: 5.81 Basic residues: 0
Polar residues: 6 Hydrophobic residues: 2
Hydrophobicity: 18.89 Boman Index: -290
Half-Life: 1.2 hour Half-Life Yeast: >20 hour
Half-Life E.Coli: >10 hour Aliphatic Index 32.22
Instability Index: 3905.56 Extinction Coefficient cystines: 1615
Absorbance 280nm: 201.88

Literature

  • PubMed ID:  7972045##17258819
  • Title:  Special evolution of neurohypophysial hormones in cartilaginous fishes: asvatocin and phasvatocin, two oxytocin-like peptides isolated from the spotted dogfish (Scyliorhinus caniculus).